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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP3K3 All Species: 34.85
Human Site: Y427 Identified Species: 69.7
UniProt: Q99759 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q99759 NP_002392.2 626 70898 Y427 Q H E R I V Q Y Y G C L R D R
Chimpanzee Pan troglodytes XP_001137191 630 70979 Y432 L H E R I V Q Y Y G C L R D P
Rhesus Macaque Macaca mulatta XP_001116198 646 73052 Y447 Q H E R I V Q Y Y G C L R D R
Dog Lupus familis XP_537600 626 70813 Y427 Q H E R I V Q Y Y G C L R D R
Cat Felis silvestris
Mouse Mus musculus Q61084 626 70757 Y427 Q H E R I V Q Y Y G C L R D R
Rat Rattus norvegicus NP_001100528 626 70672 Y427 Q H E R I V Q Y Y G C L R D R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520739 516 56869 P324 T P G A G A R P G S P L A L P
Chicken Gallus gallus XP_418076 653 73830 Y454 Q H E R I V Q Y Y G C L R D R
Frog Xenopus laevis NP_001089288 618 69717 Y419 R H D R I V Q Y Y G C L R D P
Zebra Danio Brachydanio rerio XP_688694 620 70271 Y421 H H E R I V Q Y Y G C L R D H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782621 389 43041 N197 Y F G C L E E N G T L S I F M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P23561 717 80702 V517 E L H H E N I V T Y Y G A S Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 66 89.4 97.5 N.A. 96.6 96.3 N.A. 60.2 85.5 61 77.8 N.A. N.A. N.A. N.A. 39.3
Protein Similarity: 100 78.5 90.8 99 N.A. 98.5 98.4 N.A. 65.5 90.9 74.5 85.9 N.A. N.A. N.A. N.A. 48.5
P-Site Identity: 100 86.6 100 100 N.A. 100 100 N.A. 6.6 100 80 86.6 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 86.6 100 100 N.A. 100 100 N.A. 13.3 100 93.3 86.6 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 9 0 0 0 0 0 0 17 0 0 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 75 0 0 0 0 % C
% Asp: 0 0 9 0 0 0 0 0 0 0 0 0 0 75 0 % D
% Glu: 9 0 67 0 9 9 9 0 0 0 0 0 0 0 0 % E
% Phe: 0 9 0 0 0 0 0 0 0 0 0 0 0 9 0 % F
% Gly: 0 0 17 0 9 0 0 0 17 75 0 9 0 0 0 % G
% His: 9 75 9 9 0 0 0 0 0 0 0 0 0 0 9 % H
% Ile: 0 0 0 0 75 0 9 0 0 0 0 0 9 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 9 9 0 0 9 0 0 0 0 0 9 84 0 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 0 0 0 9 0 9 0 0 0 0 0 0 0 % N
% Pro: 0 9 0 0 0 0 0 9 0 0 9 0 0 0 25 % P
% Gln: 50 0 0 0 0 0 75 0 0 0 0 0 0 0 9 % Q
% Arg: 9 0 0 75 0 0 9 0 0 0 0 0 75 0 50 % R
% Ser: 0 0 0 0 0 0 0 0 0 9 0 9 0 9 0 % S
% Thr: 9 0 0 0 0 0 0 0 9 9 0 0 0 0 0 % T
% Val: 0 0 0 0 0 75 0 9 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 75 75 9 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _